Theory 1A cell filtering diagram

This construct allows for an absence of potentially harmful membraneous filters, instead relying on the cell markers' own polarity to draw them from the stream, allowing for a far more fluid deconstruction, and replacement.

Eternal Youth by Matthew Lane is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Theory 1A addendum 5

Eternal Youth, utilizing the device, can be refined to a more accurate form than simple regulation of cell number, by adding a wireless connection that its findings can be reported, such that an influx of white blood cells is reported to the corresponding clinic, and the patient can be alerted and treated.

Addition of a second duct, to draw the aging cells into a specialized chamber, and disassembled with chemicals garnered from white blood cells, or by covering them with antigens, and releasing white blood cells, allows for a replenishment of spent cellular components,  as several filtering membranes can differentiate the fragments by size and structure due to its 1) porosity, and 2) chemical layering.

As cell levels will fluctuate with illness or age, the device must be programmed to report this, and the staff receiving this, can dismiss it as related to a harmless growth or a missing follicle. 

Macrophages and Stem cells are released intermittently, to account for aging of tissue that may not reach the device’s sensors, relying on the natural degradation of cells, and divulging sufficient stem cells to replace those that division cannot, and are guided into place using chemical signals to urge it into motion, as observed in normal expression during cellular motion. 

Sequestered from the remainder of the device, is a section containing live pig bladder components, which are stripped for their matrix, which expresses regenerative properties, and is thus guided into place using cells equipped with filamentous limbs, such that should tissue be damaged and detected due to blood loss, regeneration can be incited, allowing for internal restoration of aged organs and tissue, altering an elderly body into a youthful form.

Theory 1A addendum 5 by Matthew Lane is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Diagrams for previous addendum

Foreword: I have in the past, and may in the future neglect to name the cell properly. Some cells have a plasma membrane rather than a wall, yet I refer to the cell's border, be it composed of a membrane or wall, and thus the concept remains whether its words fail to properly define.

These diagrams are intended for the simplification of otherwise confusing subjects, and are protected by creative commons:

Eternal Youth: diagrams by

Theory 1A Addendum 4

The marker(perhaps hewn of peptides so as to avoid bodily damage, and a polar molecule to be charged, its dipole slowly drawing it toward the receptor on the cell surface, at the same rate the telomere degrades), is contained within the nucleus and rises to the cell surface to be read by the programmed device, by: its charge is opposite that of the ambient fluid, and the telomere, that it is held in limbo until one force is reduced such that it is released 1) or it is composed of materials that will react with neither substance, and rises to be recorded, by using thin strands to grasp the telomere, that once it shortens, the marker is freed, and floats about, and is drawn to the surface by the charge of its tendrils. Yet this only accounts for the blood, thus the organs and tissues are rejuvenated by sending forth a stream of macrophages into the body, to clear dead cells, or the second and more likely possibility of using cells engineered with a receptor that draws them to an antigen like structure released upon necrosis or apoptosis, attached by similar means as the marker. This cell then consumes the dead peer, then depending on the type of structure the dead cell bore i.e marrow, brain… the cell releases a second marker to its surface, from several it houses within a reprogrammed organelle, released by the type of marker it consumed reacting to the marker within itself, drawing it forth. Cycling through the body, its passage through the device releases a cell of equivalent type to that which perished, which is then guided into place by chemical signals from the implant, sending the cell through the veins, and to its location, then creating a tear much like that of some blood vessels, which are of meager size and thus allow only one cell to escape. This completed, the device waits several moments, for the cell to depart, then fuses the vein. Should the organ or tissue not require this, such a process is not initiated, and if multiple cells depart for the same location, it will allow the gap to remain open, yet this is a parlous endeavor, and thus for surface tissue to be healed and rejuvenated, a second implant is required, entrenched within the flesh, yet capable of directly impacting the skin. It sends forth a permeable membrane, that is guided by its schematics of the body garnered from a mapping prior to entry, by those implanting the device, sending a probe in the form of an engineered cell through the body, and using it to create an internal map. This guides the membrane, upon which a new layer of flesh forms, prepared to replace any damaged surface tissue by simply rising upward. This replenishes surface tissue, and a second layer beneath may be used to restore muscle and bone, or those far less swiftly accessed by veins. 

For the device to find success, it must be capable of issuing forth streams of cells sufficient to replace those slain by age, without exception, and thus the algorithm for dissemination of cells from its storage, must utilize an exact calculation of the cells not replaced by division, and account for this to retain healthy cell levels as the body ages, for as apoptosis is required for some processes, the cells become weary and incapable of holding erect the human vessel they have for so long inhabited, and thus must be replaced. This rate can be gathered by analyzing a sample, and mathematical extrapolation thereupon.

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Eternal Youth by Matthew Lane is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 

Theory 1A Addendum 3

Using a programmed device, rather than the marrow cube, allows for more accurate, and preferable results: current attempts at engineering T-cells to target cancer have been largely effective in targeting the cancer’s peptides, thus the device’ breeding chambers would be filled with these as well, release of these into the body evaded by a thin membrane whose pores allow cells to pass forth, yet thin arms extending from these cells do not allow them to escape, and the elasticity of this membrane simply urges them back into the chamber.  This device could detect the number of cells in the body by marking those that have already passed with a harmless capsule on the surface, that will be dissolved once the total number has been counted, by a T-cell programmed to detect this marker, yet rather than destroy or consume the cell, it releases the dissolving agent for the marker, removing it. This device could more accurately account for aging, and cell reduction in addition to using specially engineered cells armed with thin limbs that latch onto a cell, and move it into position, guided by a receptor on their surface, that detects chemical signals issued forth by the device, allowing for a swifter, and more accurate replacement of cells that have succumbed to age.

The device avoids clotting the blood, or disrupting ordinary flow of blood, by being housed within a small chamber of bone inserted into the chest, or shoulder. Leading to it, are several small veins of engineered cells, closed by a sphincter at the electric signal of this device, allowing it to isolate itself if so desired.

Theory 1A Addendum 2

With such a form of eternal youth, the current method of immune system reprogramming may be used to halt cancerous cells from exiting the ducts, yet this may be unnecessary: the amount of cdc4 and cell division proteins cast into the respective chambers is minuscule, sufficient only to replace the cells released, and little more. The white blood cells and macrophages in both chambers will prevent the release of dead cells into the body, and unregulated growth may trigger a lining on the walls of the chamber, unnatural numbers of cells grating against it dissolving the capsules thereupon, and releasing sufficient antigens to destroy all cells within, then the virus draws additional cells, or more can be implanted that the process will continue, yet the amount of cdc4 will change, tempered to avoid carcinogenic cells in the future.

Theory 1A Addendum

By using a shell of one of the enzymes dissolved by the nucleoplasm, the virus can enter the cell, and penetrate to the telomere, then the virus either retreats or perishes, and the marker it leaves on the telomere, to avoid chemically altering the telomere by embedding the marker, its polarity holds it at gentle repulsion from both nucleoplasm and telomere, its molecule serving little purpose yet possibly housed within a polarized capsule to hold it in stasis until the telomere is dissolved by age, releasing this marker from the cell as the repulsion of the nucleoplasm forces it outward, possibly releasing the antigens within which can force consumption of this dying or dead cell, yet this would involve a secondary virus attracted to this marker, to change the white blood cell into a stem cell, thus 2) the marker may attract a virus cell or rather an infected macrophage or white blood cell, that upon consumption, the marker enters its cytoplasm, dissolves, and in so doing releases a second capsule which is formed within a vacuole or specialized organelle(possibly an edit of the Golgi apparatus, installed by the virus, that compacts the genes of stem cells into a small packet and cell division proteins into another, which is then released into the marrow cube, as the infected cell passes through, the capsule being polarized opposite to the membrane, and thus slamming into it to cause the change in current, and opening of the muscle tissue or sphincters on the stem cell/macrophage ducts of the cube/orb, the membrane's 1) hinge like motion releasing the capsule into the stem cell breeding chamber, and the proteins into the macrophage breeding center, or 2) the enzyme shell on the capsule dissolves, and the enzymes slide along the membrane, and into the chambers.

Theory 1A

Using a cube of either programmed metal and wire, or filtering membrane filled bone, age can be cured: marrow cells are either dragged into position by a virus, or externally constructed and implanted, the latter of which is a more likely option. Viral cells then infect the body, planting chemical markers into the telomeres, which are released as the telomere shortens to critical level –age inducing level-  the membrane detects this: momentarily hardening against the marker and sending a signal across the membrane to release captured stem cell genes and other cell division proteins (harvested from the ambient blood or by the virus, as cells wither, their cell wall unable to resist the membrane, and while its less needed materials pass through to degrade within the blood, the required genes remain, sliding into pockets on the filter to be released by the jarring momentary hardening of the membrane. By releasing these proteins into the cells nearby (or releasing one of its own cells to be divided) and the Stem cell genes with them, the cube can create new cells to replace the worn versions.

One possible path, is to store several stem cells within a chamber, that is covered by the filter, and exposed when it is jarred, and the resulting spray of the proper components, can cause this stockpile to divide, replacing the released stem cell as a new version is formed.

Yet this is far from sufficient to cure age, as this only accounts for blood cell aging, and the hardening of this membrane (similar to the nano fiber water filter) may cause clotting thus:

The membrane is shrouded in electrically sensitive bacteria, which are activated, or rather a shock is released from them when the chemical  marker collides with them, causing a muscle action to open the ducts on this new, bony organ. Additonally, a section of the cube breeds Macrophage cells to eliminate the veritable droves of dead cells that will pollute the veins, and thus allowing the Stem cells to replace worn and damaged tissue and age-claimed cells, possibly by using the macrophages to eliminate the cell by rather than a chemical marker detected only by the membrane and virus, it might be a signal similar to that of an apoptic cell, inciting the macrophage to coat this aging cell amid a shroud of antigens, which then commands the white blood cells to consume it, and a stem cell will replace the missing cell. Or, the virus might change the macrophages' stores of antigens with the genes of stem cells, that an aging cell might become a stem cell, yet this might not renew it and it would succumb to the Hayfleck limit all the same. 

Nearly any type of hormone or enzyme could be bred within this device, captured within cells which are then slowly multiplied by release of cdc4, then shredded by a virus which captures the hormone and transfers it to another chamber. Thus, should the Human Growth Hormone attempt of the fountain of youth prove successful, one could change it to a self sustainable version, which would easily surpass the dose based version, at nearly any price, for one dose lasting the remainder of eternity, is quite preferable to one each day for the remainder of eternity...

Gland based Eternal Youth

This theory involves using a virus to guide the cells into position using the immune response, possibly changing them into stem cells, then fusing them therein, with either cellulose or another bonding agent, or stimulation of the ordinary paths ordinarily taken by cells to form a gland , an exocrine gland since it ravages the cells within it to release any solution. The virus will travel through the body, infecting each cell and doing nothing aside from simply adding a chemical marker to the telomere's base, that it will be released when the cell expires from age, and this chemical marker, activates the newly hewn gland. This gland then releases a new stem cell to replace the cell slain by age, thus keeping the body constant, unfading.

As depicted by the diagram, the virus can manipulate the immune pathways, drawing cells near, then chemically change them into a stem cell or leave them as they are, bonding them into a gland by momentarily permeating the cell wall, then hardening it, or by releasing cellulose from the cell through conversion of glucose.

The Virus binds a harmless chemical marker into the chromosomal telomere, deep enough to signify age.

Activated by the chemical marker, the gland shreds one cell to release the components to create another, or activates division in a cell by releasing enough cell division activators (foxo3 among others including that which is present in mitosis) to create a new cell to replace the age claimed cell, thus keeping the body's cell number level, and the body young.

Eternal Youth Theory III

Curing Human Age

Utilizing retroviruses, mankind can shear free of their fragile vessel whose flesh corrodes and retreats before time, and become immortal. This is accomplished by a retrovirus which bonds to the DNA of a cell, and changes the genes FOX03, to allow the cell to divide swiftly, then places several reactants about, to alert the cells proximate to any cancerous signals(activated by high TERT levels or unregulated division). Chloroplasts are added to the surface cells, and structures akin to plasmids allow for the energy remaining to be transferred to lower cells. Surface cells, utilize immune system recognition, to harvest bacteria, and foreign cells, and steal their nutrients to extend their own stores. The detection structures elicited by the initial virus act as proximity discerning minds, which will detect changes in the chemical field they emit, indicating less cells in their region, then divide by utilizing the FOX03 gene, with high levels of cellulose emitted by those of high TERT levels, to ensure that any cancerous cells become impermeable and unable to proliferate. Upon injection, the virus “maps” the body, or rather the reactants within it discern as a result of cellular proximity compared to that of the average youth(21yrs), then utilizing Stem cell genes(Oct4, Sox2, KLF4 and cMYC.), divides with regulation as a result of receptors that disgorge a veritable font of cellulose within cancerous cells, and forms sufficient Stem cells to repair damage, and reverse age itself, restoring the cell count and division rate to that of a human bearing only twenty years upon their feeble vessel of flesh and bone.

Mankind can become immortal, children no longer must endure mourning their parents, nor consider the eternal grief of their own children once they to are claimed by time's ragged claws. No longer will wounds harm us, or disease ail us. No longer will our vessels be shorn apart by the inscrutable torrent of time's eternal gale. Mankind will be everlasting. Mankind will be free.

Eternal Youth Theory II

Stem cells, seemingly innately search for injuries in the body, but their numbers decrease with age, thus the slower healing of elderly, and their elderly bodies. Yet with the addition of the retrovirus of my past theory, and manipulation of the four genes known to affect and effect Stem cells: Oct 4, Sox 2, KLF 4, and cMYC. It will manipulate the forehead box gene and protein set, specifically the one known to change cell proliferation: FOX03. 

Cancer, as can result from a retrovirus inserting new genomes, is warded off, by the other element of this retrovirus: cleansing. A receptor on each cell is contrived, that detects the TERT and other cancerous enzyme levels of that cell, and those adjacent. If it detects a high TERT or cancerous enzyme level or activity, it will release an enzyme that activates the receptors of the cell, that the cell will become impermeable, and if embraced in an attempt to consume through phagocytosis, it cannot be absorbed, and all the cancerous enzymes are contained within it, as the receptors change it to a Stem cell, then command it to the skin, at which point it becomes a dead cell, and descends from the body akin to a slain leaf on a tree. 

And thus, Man can live amaranthine: unfading. With Stem cell and TERT as well as other age related(youth) enzymes, but cancer warded from the body, the vessel that is Man, will no longer be one of unfired clay, but of steel.

Theory I

Can age be cured?

            Age, the disease that afflicts Man, infects them from birth and takes them in their old age, senescence. The ability to stop this, to save thousands of lives, to never see your parents die, is now within our grasp!

I have done much research in the area of age and youth, telomerase enzyme and reversatrols are obviously included in modern research; however I have an idea that I need your help proving. Have you tested this: the alteration of genes and pathways known to effect age, in addition to a change of the telomerase gene. This creates TERT as the cells divides. This is affecting one of the two cells, ergo their immortally does not effectuate tumors or cancers. This halts any aging of the body, and organs. This can be done, by a virus built of genomes synthesized in a lab.

This Virus, protected from cell overpopulation by, rescinding the senescence of one cell, which is to say, removes its age. The other "mortal" cell dies at the same rate as its quotidian compeers. Ergo, the human's age is blocked from progress; the subject is frozen at one age: twenty. The manipulation of age effecting pathways, subsuming the increase of lifespan as well as telomerase, is an supporting contrivance withal freezing senescence, age. Therefore, if the telomerase separate from support or additional measures, is not powerful enough, it is likely that combined they will remove age. Yet, alone, the Virus should make Man eternal.

Thus, I am suggesting, that a gene is created and inserted to adults, one of telomerase control. It generates this enzyme as it begins mitosis, that one of the daughter cells is immortal, however the other is not. If the body has a surplus of cells, the gene disperses the telomerase of several cells to those circumjacent, warding off cancer and tumors.

           It is thus, that Man can be immortal to some extent, unchanged by age once they attain twenty years. The elderly, can be reduced in age to twenty, and then immutably remain. The virus can be contrived, and programmed in the manner of the phage T7 genome. Built by manipulating genomes, and impelled to target the cells and alter their DNA, to ensure that at each cell division one cell is immortal, yet the other is not. And the cell releases a counter virus if its’ TERT levels are too high, that induces phagocytosis in the nearby cells, forces those cells to engulf and consume them.

Or, a second option, is that the virus simultaneously forces the cell to explode, and incites pinocytosis in the nearby cells, that the TERT overpopulated cells’ telomerase, is distributed among its siblings. Once this is done, the cells continue as normal, their virus preventing over population of telomerase, by converting it to RNA polymerases and uses it in mitosis.
So, I ask that you give me a moment of your time, the supplies, or even just pass the message on that I need the equipment. This, is the stuff of science fiction. Your help can make it real; defend the veritable droves of children, from the indescribable horror of their parent's demise at death's ragged hand.